Joseph A. Lorenzo, M.D.
Academic Title: Professor of Medicine, Director of Bone Biology Research
Education: MD, State University of New York, Downstate Medical Center
Residency: University of Illinois, Internal Medicine
Research Interests: Regulation of osteoclastogenesis by gonadal hormones and cytokines
Lee SK, and Lorenzo JA Parathyroid hormone stimulates TRANCE and inhibits osteoprotegerin mRNA expression in murine bone marrow cultures: Correlation with osteoclast-like cell formation. Endocrinology 140:3552-3561, 1999.
Okada Y, Lorenzo JA, Freeman AM, Tomita M, Morham SG, Raisz LG and Pilbeam CC. Prostaglandin G/H synthetase-2 is required for maximal stimulation of osteoclast-like cell formation in murine marrow and spleen cultures. Journal of Clinical Investigation 105:823-832, 2000.
Grčević D, Lee SK, Marusic A and Lorenzo JA. Depletion of CD4 and CD8 T lymphocytes in mice in vivo enhances 1,25 (OH)2 vitamin D3-stimulated osteoclast-like cell formation in vitro by a mechanism that is dependent on prostaglandin synthesis. Journal of Immunology 165: 4231- 4238, 2000.
Lee SK, Kalinowski J, Jastrzebski S and Lorenzo JA 1,25 (OH)2 Vitamin D3-stimulated osteoclast formation in spleen-osteoblast cocultures is mediated, in part, by enhanced IL-1a and RANK-ligand production in osteoblasts. Journal of Immunology 169: 2374-80, 2002.
Lorenzo J.A new hypothesis for how sex steroid hormones regulate bone mass. J Clin Invest. 2003 Jun;111(11):1641-3.