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David Melzer, MBBCh, MSc, PhDphoto of David Melzer, MBBCh, MSc, PhD

Academic Title
Visiting Professor, UCHC Center on Aging
Professor of Epidemiology and Public Health, University of Exeter Medical School, UK

Education
Witwatersrand University, Johannesburg, South Africa, 1981 (MBBCh)
University of London LSHTM 1987 (MSc)
University of Cambridge, 2006 (PhD)

Areas of Special Clinical Interest
Genomics of human aging
‘Big Data’ electronic medical records applications in human aging

Selected Publications

Atkins JL, Pilling LC, Ble A, Dutta A, Harries LW, Murray A, Brayne C, Robine JM, Kuchel GA, Ferrucci L, Melzer D. Longer-Lived Parents and Cardiovascular Outcomes: 8-Year Follow-Up In 186,000 U.K. Biobank Participants. J Am Coll Cardiol. 2016 Aug 23;68(8):874-5. doi: 10.1016/j.jacc.2016.05.072PMID: 27539182

Bowman K, Delgado J, Henley WE, Masoli JA, Kos K, Brayne C, Thokala P, Lafortune L, Kuchel GA, Ble A, Melzer D; as part of the Ageing Well Programme of the NIHR School for Public Health Research, England. Obesity in Older People With and Without Conditions Associated With Weight Loss: Follow-up of 955,000 Primary Care Patients. J Gerontol A Biol Sci Med Sci. 2016 Aug 4. pii: glw147

Lee BP, Pilling LC, Emond F, Flurkey K, Harrison DE, Yuan R, Peters LL, Kuchel GA, Ferrucci L, Melzer D, Harries LW. Changes in the expression of splicing factor transcripts and variations in alternative splicing are associated with lifespan in mice and humans. Aging Cell. 2016 Jun 30. doi: 10.1111/acel.12499.

Ble A, Hughes PM, Delgado J, Masoli JA, Bowman K, Zirk-Sadowski J, Mujica Mota RE, Henley WE, Melzer D. Safety and Effectiveness of Statins for Prevention of Recurrent Myocardial Infarction in 12 156 Typical Older Patients: A Quasi-Experimental Study. J Gerontol A Biol Sci Med Sci. 2016 May 4. pii: glw082. PMID: 27146371

Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, Freathy RM, Murray A, Weedon MN, Xue L, Lunetta K, Murabito JM, Harries LW, Robine JM, Brayne C, Kuchel GA, Ferrucci L, Frayling TM, Melzer D. Human longevity is influenced by many genetic variants: evidence from 75,000 UK Biobank participants. Aging (Albany NY). 2016 Mar;8(3):547-63. PMID: 27015805

Pilling LC, Joehanes R, Kacprowski T, Peters M, Jansen R, Karasik D, Kiel DP, Harries LW, Teumer A, Powell J, Levy D, Lin H, Lunetta K, Munson P, Bandinelli S, Henley W, Hernandez D, Singleton A, Tanaka T, van Grootheest G, Hofman A, Uitterlinden AG, Biffar R, Gläser S, Homuth G, Malsch C, Völker U, Penninx B, van Meurs JB, Ferrucci L, Kocher T, Murabito J, Melzer D. Gene transcripts associated with muscle strength: a CHARGE meta-analysis of 7,781 persons. Physiol Genomics. 2016 Jan;48(1):1-11. doi: 10.1152/physiolgenomics.00054.2015. Epub 2015 Oct 20. PMID: 26487704

Pilling LC, Joehanes R, Melzer D, Harries LW, Henley W, Dupuis J, Lin H, Mitchell M, Hernandez D, Ying SX, Lunetta KL, Benjamin EJ, Singleton A, Levy D, Munson P, Murabito JM, Ferrucci L. Gene expression markers of age-related inflammation in two human cohorts. Exp Gerontol. 2015 Jun 16. pii: S0531-5565(15)00188-6. doi: 10.1016/j.exger.2015.05.012. PMID: 26087330

Holly AC, Melzer D, Pilling LC, Fellows AC, Tanaka T, Ferrucci L, Harries LW. Changes in splicing factor expression are associated with advancing age in man. Mech Ageing Dev. 2013 Sep;134(9):356-66. doi: 10.1016/j.mad.2013.05.006. Epub 2013 Jun 6. PMID: 23747814

Dutta A, Henley W, Robine JM, Langa KM, Wallace RB, Melzer D. Longer lived parents: protective associations with cancer incidence and overall mortality. J Gerontol A Biol Sci Med Sci. 2013 Nov;68(11):1409-18. doi: 10.1093/gerona/glt061. Epub 2013 May 16. PMID: 23685624

Holly AC, Melzer D, Pilling LC, Henley W, Hernandez DG, Singleton AB, Bandinelli S, Guralnik JM, Ferrucci L, Harries LW. Towards a gene expression biomarker set for human biological age. Aging Cell. 2013 Apr;12(2):324-6. doi: 10.1111/acel.12044. Epub 2013 Jan 30. PMID: 23311345

Harries LW, Hernandez D, Henley W, Wood AR, Holly AC, Bradley-Smith RM, Yaghootkar H, Dutta A, Murray A, Frayling TM, Guralnik JM, Bandinelli S, Singleton A, Ferrucci L, Melzer D. Human aging is characterized by focused changes in gene expression and deregulation of alternative splicing. Aging Cell. 2011 Oct;10(5):868-78. PMID: 21668623

Dutta A, Henley W, Lang I, Llewellyn D, Guralnik J, Wallace RB, Melzer D. Predictors of extraordinary survival in the Iowa established populations for epidemiologic study of the elderly: cohort follow-up to "extinction".  J Am Geriatr Soc. 2011 Jun;59(6):963-71. PMID: 21649635

Educational Contribution 
Fellows (MD)

Contact Information
Email: melzer@uchc.edu or d.melzer@exeter.ac.uk

  
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